GNAI1 Back

guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1

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NCBI Description of GNAI1

Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. The protein encoded by this gene represents the alpha subunit of an inhibitory complex. The encoded protein is part of a complex that responds to beta-adrenergic signals by inhibiting adenylate cyclase. Two transcript variants encoding different isoforms have been found for this gene.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


GNAI1 is highly significantly mutated in
GNAI1 is significantly mutated in
GNAI1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for GNAI1