GLS2 Back

glutaminase 2 (liver, mitochondrial)

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NCBI Description of GLS2

The protein encoded by this gene is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. This protein is functionally similar to the kidney glutaminase but is a little smaller in size. Originally thought to be liver-specific, this protein has been found in other tissues as well. At least one transcribed pseudogene has been found for this gene.

Community Annotation of GLS2 Add / Edit GLS2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GLS2 is highly significantly mutated in
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GLS2 is significantly mutated in
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GLS2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for GLS2