GLIS3 Back

GLIS family zinc finger 3

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NCBI Description of GLIS3
This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein with five C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the development of pancreatic beta cells, the thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only two have been determined.

Community Annotation of GLIS3 Add / Edit GLIS3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GLIS3 is highly significantly mutated in
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GLIS3 is significantly mutated in
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GLIS3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GLIS3