GLI1 Back

glioma-associated oncogene homolog 1 (zinc finger protein)

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NCBI Description of GLI1

This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of GLI1 Add / Edit GLI1: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


GLI1 is highly significantly mutated in
GLI1 is significantly mutated in
GLI1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for GLI1