GIP Back

gastric inhibitory polypeptide

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NCBI Description of GIP
This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion.

Community Annotation of GIP Add / Edit GIP: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GIP is highly significantly mutated in
(none)
GIP is significantly mutated in
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GIP is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GIP