GIF Back

gastric intrinsic factor (vitamin B synthesis)

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NCBI Description of GIF
This gene is a member of the cobalamin transport protein family. It encodes a glycoprotein secreted by parietal cells of the gastric mucosa and is required for adequate absorption of vitamin B12. Vitamin B12 is necessary for erythrocyte maturation and mutations in this gene may lead to congenital pernicious anemia.

Community Annotation of GIF Add / Edit GIF: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GIF is highly significantly mutated in
(none)
GIF is significantly mutated in
(none)
GIF is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GIF