GGTLC1 Back

gamma-glutamyltransferase light chain 1

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NCBI Description of GGTLC1

This gene encodes a member of the gamma-glutamyl transpeptidase (GGT) family, which are important in the metabolism of glutathione. The most ubiquitously expressed human GGT gene, GGT1, encodes a single transmembrane polypeptide that is post-translationally processed to form a heavy and a light chain. In contrast, the product of this gene only contains homology to the light chain region, and lacks a transmembrane domain. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Community Annotation of GGTLC1 Add / Edit GGTLC1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GGTLC1 is highly significantly mutated in
(none)
GGTLC1 is significantly mutated in
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GGTLC1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for GGTLC1