GGPS1 Back

geranylgeranyl diphosphate synthase 1

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NCBI Description of GGPS1
This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene.

Community Annotation of GGPS1 Add / Edit GGPS1: Annotations

No community annotations yet for GGPS1.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GGPS1 is highly significantly mutated in
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GGPS1 is significantly mutated in
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GGPS1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GGPS1