GGA3 Back

golgi associated, gamma adaptin ear containing, ARF binding protein 3

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of GGA3
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants have been identified in this gene.

Community Annotation of GGA3 Add / Edit GGA3: Annotations

No community annotations yet for GGA3.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GGA3 is highly significantly mutated in
(none)
GGA3 is significantly mutated in
(none)
GGA3 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GGA3