GFRA4 Back

GDNF family receptor alpha 4

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NCBI Description of GFRA4
The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Community Annotation of GFRA4 Add / Edit GFRA4: Annotations

No community annotations yet for GFRA4.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GFRA4 is highly significantly mutated in
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GFRA4 is significantly mutated in
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GFRA4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GFRA4