GEMIN8 Back

gem (nuclear organelle) associated protein 8

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NCBI Description of GEMIN8
The protein encoded by this gene is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. The encoded protein binds to both SMN1 and the GEMIN6/GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GEMIN8 is highly significantly mutated in
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GEMIN8 is significantly mutated in
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GEMIN8 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GEMIN8