GEMIN4 Back

gem (nuclear organelle) associated protein 4

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NCBI Description of GEMIN4
The product of this gene is part of a large complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spliceosomes required for pre-mRNA splicing in the nucleus. The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Community Annotation of GEMIN4 Add / Edit GEMIN4: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GEMIN4 is highly significantly mutated in
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GEMIN4 is significantly mutated in
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GEMIN4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GEMIN4