GDF2 Back

growth differentiation factor 2

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NCBI Description of GDF2
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein plays a role in the adult liver and in differentiation of cholinergic central nervous system neurons.

Community Annotation of GDF2 Add / Edit GDF2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GDF2 is highly significantly mutated in
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GDF2 is significantly mutated in
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GDF2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GDF2