GDF15 Back

growth differentiation factor 15

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NCBI Description of GDF15
Bone morphogenetic proteins (e.g., BMP9; MIM 605120) are members of the transforming growth factor-beta (see TGFB1; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.[supplied by OMIM, Oct 2009].

Community Annotation of GDF15 Add / Edit GDF15: Annotations

No community annotations yet for GDF15.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GDF15 is highly significantly mutated in
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GDF15 is significantly mutated in
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GDF15 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GDF15