GCKR Back

glucokinase (hexokinase 4) regulator

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of GCKR

This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY).

Community Annotation of GCKR Add / Edit GCKR: Annotations

No community annotations yet for GCKR.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GCKR is highly significantly mutated in
(none)
GCKR is significantly mutated in
(none)
GCKR is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for GCKR