GCHFR Back

GTP cyclohydrolase I feedback regulator

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NCBI Description of GCHFR
GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GCHFR is highly significantly mutated in
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GCHFR is significantly mutated in
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GCHFR is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GCHFR