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NCBI Description of GCG

The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. Sequence Note: A downstream translational start codon is selected for this RefSeq based on transcript support and on the presence of a predicted signal peptide in the protein N-terminus. Several upstream in-frame start codons are also present with sparse transcript support, and would result in proteins that are up to 83 aa longer at the N-terminus and lack predicted signal peptides. Leaky scanning by ribosomes may allow translation initiation at the downstream start codon.

Community Annotation of GCG Add / Edit GCG: Annotations

No community annotations yet for GCG.
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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


GCG is highly significantly mutated in
GCG is significantly mutated in
GCG is near significance in

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Data details

Mutation list for GCG