GBF1 Back

golgi-specific brefeldin A resistance factor 1

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NCBI Description of GBF1
This gene encodes a member of the Sec7 domain family. The encoded protein is a guanine nucleotide exchange factor that regulates the recruitment of proteins to membranes by mediating GDP to GTP exchange. The encoded protein is localized to the Golgi apparatus and plays a role in vesicular trafficking by activating ADP ribosylation factor 1. The encoded protein has also been identified as an important host factor for viral replication. Multiple transcript variants have been observed for this gene.

Community Annotation of GBF1 Add / Edit GBF1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GBF1 is highly significantly mutated in
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GBF1 is significantly mutated in
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GBF1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GBF1