GATM Back

glycine amidinotransferase (L-arginine:glycine amidinotransferase)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of GATM
This gene encodes a mitochondrial enzyme that belongs to the amidinotransferase family. This enzyme is involved in creatine biosynthesis, whereby it catalyzes the transfer of a guanido group from L-arginine to glycine, resulting in guanidinoacetic acid, the immediate precursor of creatine. Mutations in this gene cause arginine:glycine amidinotransferase deficiency, an inborn error of creatine synthesis characterized by mental retardation, language impairment, and behavioral disorders.

Community Annotation of GATM Add / Edit GATM: Annotations

No community annotations yet for GATM.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GATM is highly significantly mutated in
(none)
GATM is significantly mutated in
(none)
GATM is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GATM