glycyl-tRNA synthetase

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NCBI Description of GARS

This gene encodes glycyl-tRNA synthetase, one of the aminoacyl-tRNA synthetases that charge tRNAs with their cognate amino acids. The encoded enzyme is an (alpha)2 dimer which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis.

Community Annotation of GARS Add / Edit GARS: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


GARS is highly significantly mutated in
GARS is significantly mutated in
GARS is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for GARS