glyceraldehyde-3-phosphate dehydrogenase

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NCBI Description of GAPDH

The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains. Many pseudogenes similar to this locus are present in the human genome. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of GAPDH Add / Edit GAPDH: Annotations

No community annotations yet for GAPDH.
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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


GAPDH is highly significantly mutated in
GAPDH is significantly mutated in
GAPDH is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for GAPDH