GAPDH Back

glyceraldehyde-3-phosphate dehydrogenase

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NCBI Description of GAPDH
The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains. Many pseudogenes similar to this locus are present in the human genome. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of GAPDH Add / Edit GAPDH: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GAPDH is highly significantly mutated in
(none)
GAPDH is significantly mutated in
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GAPDH is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GAPDH