GAN Back

giant axonal neuropathy (gigaxonin)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of GAN

This gene encodes a member of the cytoskeletal BTB/kelch (Broad-Complex, Tramtrack and Bric a brac) repeat family. The encoded protein plays a role in neurofilament architecture and is involved in mediating the ubiquitination and degradation of some proteins. Defects in this gene are a cause of giant axonal neuropathy (GAN). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.

Community Annotation of GAN Add / Edit GAN: Annotations

No community annotations yet for GAN.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GAN is highly significantly mutated in
(none)
GAN is significantly mutated in
(none)
GAN is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for GAN