GABRB1 Back

gamma-aminobutyric acid (GABA) A receptor, beta 1

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NCBI Description of GABRB1
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

GABRB1 is highly significantly mutated in
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GABRB1 is significantly mutated in
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GABRB1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for GABRB1