gamma-aminobutyric acid (GABA) A receptor, alpha 2

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NCBI Description of GABRA2

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


GABRA2 is highly significantly mutated in
GABRA2 is significantly mutated in
GABRA2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for GABRA2