NCBI Description of FTO
|This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes.|
Community Annotation of FTO Add / Edit FTO: Annotations
No community annotations yet for FTO.
• "Mouse over" a mutation to see details.
Click on a tumor type to see its full list of significant genes.