FRMPD2 Back

FERM and PDZ domain containing 2

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NCBI Description of FRMPD2

This gene encodes a peripheral membrane protein and is located in a region of chromosome 10q that contains a segmental duplication. This copy of the gene is full-length and is in the telomeric duplicated region. Two other more centromerically proximal copies of the gene are partial and may represent pseudogenes. This full-length gene appears to function in the establishment and maintenance of cell polarization. The protein is recruited to cell-cell junctions in an E-cadherin-dependent manner, and is selectively localized at the basolateral membrane in polarized epithelial cells. Alternative splicing results in multiple transcript variants.

Community Annotation of FRMPD2 Add / Edit FRMPD2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

FRMPD2 is highly significantly mutated in
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FRMPD2 is significantly mutated in
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FRMPD2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for FRMPD2