FRMD3 Back

FERM domain containing 3

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NCBI Description of FRMD3

The protein encoded by this gene is a single pass membrane protein primarily found in ovaries. A similar protein in erythrocytes helps determine the shape of red blood cells, but the function of the encoded protein has not been determined. There is some evidence that this is a tumor suppressor gene, and there is also evidence linking defects in this gene to susceptibility to diabetic nephropathy in type 1 diabetes. Several transcript variants encoding different isoforms have been found for this gene.

Community Annotation of FRMD3 Add / Edit FRMD3: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


FRMD3 is highly significantly mutated in
FRMD3 is significantly mutated in
FRMD3 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for FRMD3