FREM2 Back

FRAS1 related extracellular matrix protein 2

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NCBI Description of FREM2
This gene encodes a membrane protein that belongs to the FRAS1 family. This extracellular matrix protein is thought to be required for maintaining the integrity of the skin epithelium and the differentiated state of renal epithelia. The protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions during morphogenetic processes. Mutations in this gene are associated with Fraser syndrome.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

FREM2 is highly significantly mutated in
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FREM2 is significantly mutated in
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FREM2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for FREM2