FRAT1 Back

frequently rearranged in advanced T-cell lymphomas

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NCBI Description of FRAT1

The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.

Community Annotation of FRAT1 Add / Edit FRAT1: Annotations

No community annotations yet for FRAT1.
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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


FRAT1 is highly significantly mutated in
FRAT1 is significantly mutated in
FRAT1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for FRAT1