FOXP3 Back

forkhead box P3

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NCBI Description of FOXP3

The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.

Community Annotation of FOXP3 Add / Edit FOXP3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

FOXP3 is highly significantly mutated in
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FOXP3 is significantly mutated in
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FOXP3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for FOXP3