FOXO3 Back

forkhead box O3

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NCBI Description of FOXO3
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.

Community Annotation of FOXO3 Add / Edit FOXO3: Annotations

No community annotations yet for FOXO3.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

FOXO3 is highly significantly mutated in
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FOXO3 is significantly mutated in
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FOXO3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for FOXO3