FOXC1 Back

forkhead box C1

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NCBI Description of FOXC1

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. Sequence Note: This RefSeq record was created from genomic sequence data because mRNA transcripts were not available for the full length of the gene. The extent of this transcript is supported by orthologous mouse data.

Community Annotation of FOXC1 Add / Edit FOXC1: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


FOXC1 is highly significantly mutated in
FOXC1 is significantly mutated in
FOXC1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for FOXC1