FOXA2 Back

forkhead box A2

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NCBI Description of FOXA2
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene.

Community Annotation of FOXA2 Add / Edit FOXA2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

FOXA2 is highly significantly mutated in
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FOXA2 is significantly mutated in
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FOXA2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for FOXA2