FMO2 Back

flavin containing monooxygenase 2 (non-functional)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of FMO2
The flavin-containing monooxygenases are NADPH-dependent enzymes that catalyze the oxidation of many drugs and xenobiotics. In most mammals, there is a flavin-containing monooxygenase that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, in humans, this enzyme is truncated and is probably rapidly degraded. The protein encoded by this gene represents the truncated form and apparently has no catalytic activity. A functional allele found in African Americans has been reported, but no sequence evidence has been deposited to support the finding. This gene is found in a cluster with the FMO1, FMO3, and FMO4 genes on chromosome 1.

Community Annotation of FMO2 Add / Edit FMO2: Annotations

No community annotations yet for FMO2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

FMO2 is highly significantly mutated in
(none)
FMO2 is significantly mutated in
(none)
FMO2 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for FMO2