FLVCR2 Back

feline leukemia virus subgroup C cellular receptor family, member 2

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NCBI Description of FLVCR2
This gene encodes a member of the major facilitator superfamily. The encoded transmembrane protein is a calcium transporter. Unlike the related protein feline leukemia virus subgroup C receptor 1, the protein encoded by this locus does not bind to feline leukemia virus subgroup C envelope protein. The encoded protein may play a role in development of brain vascular endothelial cells, as mutations at this locus have been associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Alternatively spliced transcript variants have been described.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

FLVCR2 is highly significantly mutated in
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FLVCR2 is significantly mutated in
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FLVCR2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for FLVCR2