FLNA Back

filamin A, alpha (actin binding protein 280)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of FLNA
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of FLNA Add / Edit FLNA: Annotations

No community annotations yet for FLNA.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

FLNA is highly significantly mutated in
(none)
FLNA is significantly mutated in
(none)
FLNA is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for FLNA