FLI1 Back

Friend leukemia virus integration 1

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NCBI Description of FLI1
This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants.

Community Annotation of FLI1 Add / Edit FLI1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

FLI1 is highly significantly mutated in
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FLI1 is significantly mutated in
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FLI1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for FLI1