FHL3 Back

four and a half LIM domains 3

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of FHL3

The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of FHL3 Add / Edit FHL3: Annotations

No community annotations yet for FHL3.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

FHL3 is highly significantly mutated in
(none)
FHL3 is significantly mutated in
(none)
FHL3 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for FHL3