NCBI Description of FHIT
|This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene.|
Community Annotation of FHIT Add / Edit FHIT: Annotations
No community annotations yet for FHIT.
• "Mouse over" a mutation to see details.
Click on a tumor type to see its full list of significant genes.