FGF3 Back

fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog)

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NCBI Description of FGF3
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation.

Community Annotation of FGF3 Add / Edit FGF3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

FGF3 is highly significantly mutated in
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FGF3 is significantly mutated in
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FGF3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for FGF3