FGF23 Back

fibroblast growth factor 23

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of FGF23

This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC).

Community Annotation of FGF23 Add / Edit FGF23: Annotations

No community annotations yet for FGF23.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


FGF23 is highly significantly mutated in
FGF23 is significantly mutated in
FGF23 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for FGF23