FEZ1 Back

fasciculation and elongation protein zeta 1 (zygin I)

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NCBI Description of FEZ1

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described.

Community Annotation of FEZ1 Add / Edit FEZ1: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


FEZ1 is highly significantly mutated in
FEZ1 is significantly mutated in
FEZ1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for FEZ1