FECH Back

ferrochelatase (protoporphyria)

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NCBI Description of FECH
The protein encoded by this gene is localized to the mitochondrion, where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome 3.

Community Annotation of FECH Add / Edit FECH: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

FECH is highly significantly mutated in
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FECH is significantly mutated in
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FECH is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for FECH