FDFT1 Back

farnesyl-diphosphate farnesyltransferase 1

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NCBI Description of FDFT1
This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene.

Community Annotation of FDFT1 Add / Edit FDFT1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

FDFT1 is highly significantly mutated in
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FDFT1 is significantly mutated in
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FDFT1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for FDFT1