FBXW8 Back

F-box and WD repeat domain containing 8

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of FBXW8

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

Community Annotation of FBXW8 Add / Edit FBXW8: Annotations

No community annotations yet for FBXW8.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

FBXW8 is highly significantly mutated in
(none)
FBXW8 is significantly mutated in
(none)
FBXW8 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for FBXW8