FBXW12 Back

F-box and WD repeat domain containing 12

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of FBXW12
Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008].

Community Annotation of FBXW12 Add / Edit FBXW12: Annotations

No community annotations yet for FBXW12.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

FBXW12 is highly significantly mutated in
(none)
FBXW12 is significantly mutated in
(none)
FBXW12 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for FBXW12