NCBI Description of FBXW12
|Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008].|
Community Annotation of FBXW12 Add / Edit FBXW12: Annotations
No community annotations yet for FBXW12.
Click on a tumor type to see its full list of significant genes.