FBXO46 Back

F-box protein 46

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of FBXO46

Members of the F-box protein family, such as FBXO46, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.

Community Annotation of FBXO46 Add / Edit FBXO46: Annotations

No community annotations yet for FBXO46.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

FBXO46 is highly significantly mutated in
(none)
FBXO46 is significantly mutated in
(none)
FBXO46 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for FBXO46