FBXO42 Back

F-box protein 42

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NCBI Description of FBXO42
Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (SKP1A; MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Dec 2010].

Community Annotation of FBXO42 Add / Edit FBXO42: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

FBXO42 is highly significantly mutated in
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FBXO42 is significantly mutated in
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FBXO42 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for FBXO42