FBXO18 Back

F-box protein, helicase, 18

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of FBXO18
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

Community Annotation of FBXO18 Add / Edit FBXO18: Annotations

No community annotations yet for FBXO18.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

FBXO18 is highly significantly mutated in
(none)
FBXO18 is significantly mutated in
(none)
FBXO18 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for FBXO18