FBXO16 Back

F-box protein 16

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NCBI Description of FBXO16
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of FBXO16 Add / Edit FBXO16: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

FBXO16 is highly significantly mutated in
FBXO16 is significantly mutated in
FBXO16 is near significance in
Lung adenocarcinoma
LUAD
8 patients (1%)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for FBXO16